[CAS NO. 14513-15-6] Cambinol
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PRODUCTS SPECIFICATIONS [14513-15-6]
Store
Catalog
SLK-S5913
Brand
Selleck
CAS
14513-15-6
DESCRIPTION [14513-15-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 360.43 |
| Molecular Formula | C21H16N2O2S |
| SMILES | O=C(C(CC1=C2C=CC=CC2=CC=C1O)=C(C3=CC=CC=C3)N4)NC4=S |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
Cambinol is a novel uncompetitive inhibitor with a K i value of 7 μM (IC50 = 5 ± 1 μM).
Targets
| nSMase2 [1] (Cell-free assay) |
| 7 μM(Ki) |
In vitro
Cambinol decreases tumor necrosis factor-α or interleukin-1 β-induced increases of ceramide and cell death in primary neurons. Cambinol is an inhibitor of the NAD-dependent deacetylase activity of sirtuin, human silent information regulator type 1/2 (SIRT1/2), with IC50 values of 56 μM and 59 μM for SIRT1 and SIRT2, respectively. Cambinol induces apoptosis in BCL6-expressing Burkitt lymphoma cell lines. Cambinol is approximately a 10-fold more potent human nSMase2 inhibitor compared to SIRT1/2. Cambinol is a potent inhibitor of acidic pHe-mediated anterograde lysosome trafficking.
In vivo
Cambinol is well tolerated in mice and has potent antitumor activity in vivo.
References
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