Overview
| MDL | MFCD03140195 |
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| Molecular Weight | 437.35 |
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| Molecular Formula | C19H21BrN2O3S |
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| SMILES | O=C(NC1=CC=CC(Br)=C1)C2=CC=CC(S(=O)(N3CCCCCC3)=O)=C2 |
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For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg |
| 1 mM | 2.2865 mL | 11.4325 mL | 22.8650 mL |
| 5 mM | 0.4573 mL | 2.2865 mL | 4.5730 mL |
| 10 mM | 0.2286 mL | 1.1432 mL | 2.2865 mL |
| 50 mM | 0.0457 mL | 0.2286 mL | 0.4573 mL |
Description
AK 7 is a brain-permeable selective inhibitor with an IC50 of 15.5 μM.
In vitro
Treatment with AK7 increases lysine 40 (K40) acetylation of α-tubulin in neuronal cells. AK7 ameliorates alpha-synuclein toxicity in vitro.