[CAS NO. 137281-23-3] Pemetrexed

Name: Pemetrexed
Brand: Arctom Scientific
SKU: SLK-S5971

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PRODUCTS SPECIFICATIONS [137281-23-3]

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Catalog

SLK-S5971

Brand

Selleck

CAS

137281-23-3

DESCRIPTION [137281-23-3]

Overview

MDL	MFCD19105065
Molecular Weight	427.41
Molecular Formula	C20H21N5O6
SMILES	C(CC1=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C1)C=2C3=C(NC2)NC(N)=NC3=O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.3397 mL	11.6984 mL	23.3967 mL
5 mM	0.4679 mL	2.3397 mL	4.6793 mL
10 mM	0.2340 mL	1.1698 mL	2.3397 mL
50 mM	0.0468 mL	0.2340 mL	0.4679 mL

Description

Pemetrexed (LY231514, Alimta) is a novel antifolate and antimetabolite for , and with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces and .

Targets

Thymidylate synthase ^[1] (Cell-free assay)	DHFR ^[1] (Cell-free assay)	GARFT ^[1] (Cell-free assay)
1.3 nM(Ki)	7.2 nM(Ki)	65 nM(Ki)

In vitro

Osimertinib+pemetrexed treatment delays the emergence of resistance relative to monotherapy in vitro, also down-regulates the expression of the anti-apoptotic gene PLK1 in PC-9 and H1975.

References

[1] Shih C, et al. Cancer Res. 1997, 57(6), 1116-1123.
[2] Iwahori K, et al. Int J Cancer. 2012, doi: 10.1002/ijc.27611.
[3] Teicher BA, et al. Clin Cancer Res. 2000, 6(3), 1016-1023.
[4] Takano N, et al. Anticancer Res. 2022 Feb;42(2):709-722.

Synonyms

L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-

L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-

1H-Pyrrolo[2,3-d]pyrimidine, L-glutamic acid deriv.

N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid

Pemetrexed

NSC 698037

N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid

(S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioic acid