[CAS NO. 36913-39-0] MPP+ iodide
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PRODUCTS SPECIFICATIONS [36913-39-0]
Store
Catalog
SLK-S6301
Brand
Selleck
CAS
36913-39-0
DESCRIPTION [36913-39-0]
Overview
| MDL | MFCD00055096 |
|---|---|
| Molecular Weight | 297.13 |
| Molecular Formula | C12H12IN |
| SMILES | C[N+]=1C=CC(=CC1)C2=CC=CC=C2.[I-] |
For research use only.
Storage
3 years-20°C(in the dark) powder
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.3655 mL | 16.8277 mL | 33.6553 mL |
| 5 mM | 0.6731 mL | 3.3655 mL | 6.7311 mL |
| 10 mM | 0.3366 mL | 1.6828 mL | 3.3655 mL |
| 50 mM | 0.0673 mL | 0.3366 mL | 0.6731 mL |
Description
MPP+ iodide (N-Methyl-4-Phenylpyridinium Iodide), the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying in substantia nigra. MPP+ induces in SH-SY5Y cells. MPP+ induces externalization in dopaminergic (DA) neurons, but internalization of in serotonergic (5-HT) neurons.
In vitro
Vacuolin-1 potently and reversibly inhibits the fusion between autophagosomes and lysosomes in mammalian cells, thereby inducing the accumulation of autophagosomes. Vacuolin-1 activates RAB5A to block autophagosome-lysosome fusion.
References
Synonyms
Pyridinium, 1-methyl-4-phenyl-, iodide (1:1)
Pyridinium, 1-methyl-4-phenyl-, iodide
1-Methyl-4-phenylpyridinium iodide
N-Methyl-4-phenylpyridinium iodide
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