[CAS NO. 1628208-23-0] CPI-455
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PRODUCTS SPECIFICATIONS [1628208-23-0]
Store
Catalog
SLK-S6389
Brand
Selleck
CAS
1628208-23-0
DESCRIPTION [1628208-23-0]
Overview
| MDL | MFCD29921343 |
|---|---|
| Molecular Weight | 278.31 |
| Molecular Formula | C16H14N4O |
| SMILES | N#CC1=C2NC(C3=CC=CC=C3)=C(C(C)C)C(N2N=C1)=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.5931 mL | 17.9656 mL | 35.9312 mL |
| 5 mM | 0.7186 mL | 3.5931 mL | 7.1862 mL |
| 10 mM | 0.3593 mL | 1.7966 mL | 3.5931 mL |
| 50 mM | - | - | - |
Targets
| KDM5 [1] (in enzymatic assays) |
| 10 nM |
In vitro
CPI-455 mediates KDM5 inhibition, elevates global levels of H3K4 trimethylation (H3K4me3) and decreases the number of DTPs in multiple cancer cell line models treated with standard chemotherapy or targeted agents.
References
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