[CAS NO. 146986-50-7] Y-27632

Name: Y-27632
Brand: Arctom Scientific
SKU: SLK-S6390

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PRODUCTS SPECIFICATIONS [146986-50-7]

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Catalog

SLK-S6390

Brand

Selleck

CAS

146986-50-7

DESCRIPTION [146986-50-7]

Overview

MDL	-
Molecular Weight	247.34
Molecular Formula	C14H21N3O
SMILES	C(NC=1C=CN=CC1)(=O)[C@H]2CC[C@]([C@@H](C)N)(CC2)[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

Y-27632 is a selective ROCK1 and ROCK2 inhibitor with a Ki of 140 nM and 300nM in a cell-free assay, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.

Targets

ROCK1 ^[1] (Cell-free assay)	ROCK2 ^[1] (Cell-free assay)
140 nM(Ki)	300 nM(Ki)

In vitro

Y-27632 primes human induced pluripotent stem cells (hIPSCs) to selectively differentiate towards mesendodermal lineage via epithelial-mesenchymal transition-like modulation.

References

[1] M Uehata, et al. Nature. 1997 Oct 30;389(6654):990-4.
[2] Ma J, et al. Adv Sci (Weinh). 2022 Mar 22:e2106075.
[3] Mertsch S, et al. Ocul Surf. 2021 Oct;22:213-223.

Synonyms

Cyclohexanecarboxamide, 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-, trans-

Cyclohexanecarboxamide, 4-(1-aminoethyl)-N-4-pyridinyl-, [4(R)-trans]-

trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide

Y 27632

(R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)cyclohexanecarboxamide

(+)-(R)-trans-4-(1-Aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide