[CAS NO. 574013-66-4] fexaramine

Name: fexaramine
Brand: Arctom Scientific
SKU: SLK-S6413

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PRODUCTS SPECIFICATIONS [574013-66-4]

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Catalog

SLK-S6413

Brand

Selleck

CAS

574013-66-4

DESCRIPTION [574013-66-4]

Overview

MDL	MFCD09971007
Molecular Weight	496.64
Molecular Formula	C32H36N2O3
SMILES	N(C(=O)C1CCCCC1)(CC2=CC=C(C=C2)C3=CC=C(N(C)C)C=C3)C4=CC(/C=C/C(OC)=O)=CC=C4

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

Fexaramine is a potent, selective agonist with an EC50 of 25 nM and it displays no activity at hRXRα, hPPARα, hPPARγ, hPPARδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ and hVDR receptors.

Targets

FXR ^[1]

25 nM(EC50)

References

[1] Downes M, et al. Mol Cell. 2003, 11(4):1079-92.

Synonyms

2-Propenoic acid, 3-[3-[(cyclohexylcarbonyl)[[4′-(dimethylamino)[1,1′-biphenyl]-4-yl]methyl]amino]phenyl]-, methyl ester, (2E)-

Methyl (2E)-3-[3-[(cyclohexylcarbonyl)[[4′-(dimethylamino)[1,1′-biphenyl]-4-yl]methyl]amino]phenyl]-2-propenoate

Fexaramine