[CAS NO. 1094873-14-9]  JNJ 31020028

JNJ-31020028 is assayed by binding in a panel of 50 receptors, ion channels, and transporters assays including adenosine (A1, A2A, A3), adrenergic (α1, α2, β1), angiotensin (AT1), dopamine (D1, D2), bradykinin (B2), cholecystokinin (CCKA), galanin (GAL2), melatonin (ML1), muscarinic (M1, M2, M3), neurotensin (NT1), neurokinin (NK2, NK3), opiate (μ, κ, δ), serotonin (5-HT1A, 5-HT1B, 5-HT2A, 5-HT3, 5-HT5A, 5-HT6, 5-HT7), somatostatin, vasopressin (V1a), norepinephrine transporter, dopamine transporter, and ion channels (sodium, calcium, potassium, and chloride). The Y2 antagonist at concentrations up to 10μM has no significant affinity for any receptor/transporter/ion channel (<50% inhibition at 10μM) other than the Y2 receptor. Selectivity of Y2 antagonist is further evaluated in a panel comprised of 65 kinases. JNJ-31020028 (10μM) does not inhibit any of the kinase included in the panel.