[CAS NO. 898800-26-5] AZ876
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PRODUCTS SPECIFICATIONS [898800-26-5]
Store
Catalog
SLK-S6427
Brand
Selleck
CAS
898800-26-5
DESCRIPTION [898800-26-5]
Overview
| MDL | MFCD30377191 |
|---|---|
| Molecular Weight | 439.57 |
| Molecular Formula | C24H29N3O3S |
| SMILES | O=C(C(NC1=CC=C(N2CCCCC2)C=C1)=C3C4=CC=CC=C4)N(C(C)(C)C)S3(=O)=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
AZ876 is a novel high-affinity agonist with Ki values of 0.007 μM and 0.011 μM for human LXRα and LXRβ respectively.
In vitro
In binding assays, AZ876 is 25-fold and 2.5-fold more potent than GW3965 on human (h)LXRα and hLXRβ respectively. In reporter transactivation assays, AZ876 is 196-fold and fivefold more potent than GW3965 on hLXRα and hLXRβ respectively. AZ876 is also more potent than GW3965 on mouse (m)LXRα (248-fold) and mLXRβ (10.5-fold). AZ876 is four- to sevenfold more potent than GW3965 on the expression of ABCA1 mRNA in hamster and human blood PMN cells. AZ876 is highly selective with respect to other nuclear hormone receptors, including retinoid X receptor, farnesoid X receptor, thyroid hormone receptor (TR)α or TRβ, when tested in agonist mode in fluorescence resonance energy transfer assays.
References
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