[CAS NO. 268203-93-6] Udenafil

Name: Udenafil
Brand: Arctom Scientific
SKU: SLK-S6433

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PRODUCTS SPECIFICATIONS [268203-93-6]

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Catalog

SLK-S6433

Brand

Selleck

CAS

268203-93-6

DESCRIPTION [268203-93-6]

Overview

MDL	MFCD20275557
Molecular Weight	516.66
Molecular Formula	C25H36N6O4S
SMILES	C(CC)C=1C2=C(C(=O)N=C(N2)C3=C(OCCC)C=CC(S(NCCC4N(C)CCC4)(=O)=O)=C3)N(C)N1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.9355 mL	9.6775 mL	19.3551 mL
5 mM	0.3871 mL	1.9355 mL	3.8710 mL
10 mM	0.1936 mL	0.9678 mL	1.9355 mL
50 mM	0.0387 mL	0.1936 mL	0.3871 mL

Description

Udenafil is a potent antagonist of human with an IC50 of 8.25 nM and a comparable selectivity profile as sildenafil for the other PDEs.

Targets

PDE5 ^[1] (Cell-free assay)	PDE3 ^[1] (Cell-free assay)	PDE6 ^[1] (Cell-free assay)	PDE2 ^[1] (Cell-free assay)
8.25 nM	52 nM	53.3 nM	101 nM

In vitro

The inhibitory effect of udenafil on PDE5 is about 150-fold greater than that on PDE1 (selectivity ratio of 149). PDE11 selectivity of udenafil (selectivity ratio of 96) is relatively high, indicating a very low probability of inhibition of PDE11 at therapeutic doses of udenafil. The IC50 values for PDE2, PDE3, and PDE6 of udenafil are 101±15.1 nM, 52.0±3.53 nM, and 53.3±2.47 nM respectively.

References

[1] Min Chul Cho, et al. Ther Clin Risk Manag. 2014, 10: 341-354.
[2] Sung Gu Kang, et al. Ther Adv Urol. 2013, 5(2): 101-110.

Synonyms

Benzenesulfonamide, 3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-[2-(1-methyl-2-pyrrolidinyl)ethyl]-4-propoxy-

Benzenesulfonamide, 3-(4,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-[2-(1-methyl-2-pyrrolidinyl)ethyl]-4-propoxy-

3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-[2-(1-methyl-2-pyrrolidinyl)ethyl]-4-propoxybenzenesulfonamide

DA 8159

Udenafil

Zydena

3-(1-Methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-(2-(1-methylpyrrolidin-2-yl)ethyl)-4-propoxybenzenesulfonamide

3-(1-Methyl-7-oxo-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-[2-(1-methylpyrrolidin-2-yl)ethyl]-4-propoxybenzenesulfonamide