[CAS NO. 555-60-2] CCCP

Name: CCCP
Brand: Arctom Scientific
SKU: SLK-S6494

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PRODUCTS SPECIFICATIONS [555-60-2]

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Catalog

SLK-S6494

Brand

Selleck

CAS

555-60-2

DESCRIPTION [555-60-2]

Overview

MDL	-
Molecular Weight	204.62
Molecular Formula	C9H5ClN4
SMILES	N(N=C(C#N)C#N)C1=CC(Cl)=CC=C1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	4.8871 mL	24.4355 mL	48.8711 mL
5 mM	0.9774 mL	4.8871 mL	9.7742 mL
10 mM	0.4887 mL	2.4436 mL	4.8871 mL
50 mM	0.0977 mL	0.4887 mL	0.9774 mL

Description

CCCP (Carbonyl cyanide m-chlorophenyl hydrazone, Carbonyl cyanide 3-chlorophenylhydrazone), an inhibitor, is a protonophore mitochondrial uncoupler that increases membrane permeability to protons, leading to a disruption in the mitochondrial membrane potential. Carbonyl cyanide 3-chlorophenylhydrazone (CCCP), the protonophore, can inhibits IFN-β production via disrupting mitochondrial membrane potential (MMP).

In vitro

CCCP, a drug perturbing adenosine triphosphate synthesis by transporting protons across the mitochondrial inner membrane, reduces the spheroid-forming cell (SFC) frequency, indicating sensitivity of stem-like cells towards oxidative phosphorylation (OXPHOS) inhibition.

References

[1] Zowada MK, et al. Cancers (Basel). 2021;13(5):1097.
[2] Sinha D, et al. Sci Rep. 2017 Mar 17;7:44419.

Synonyms

Propanedinitrile, 2-[2-(3-chlorophenyl)hydrazinylidene]-

Propanedinitrile, [(3-chlorophenyl)hydrazono]-

Mesoxalonitrile, (m-chlorophenyl)hydrazone

2-[2-(3-Chlorophenyl)hydrazinylidene]propanedinitrile

Carbonyl cyanide (3-chlorophenyl)hydrazone

CCP

CCCP

Carbonyl cyanide (m-chlorophenyl)hydrazone

[(3-Chlorophenyl)hydrazono]malononitrile

3-Chlorophenylhydrazonopropanedinitrile

NSC 88124

2-[(3-Chlorophenyl)hydrazinylidene]propanedinitrile

2-[(3-Chlorophenyl)-hydrazono]malononitrile