[CAS NO. 362003-83-6] NVP 231
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PRODUCTS SPECIFICATIONS [362003-83-6]
Store
Catalog
SLK-S6501
Brand
Selleck
CAS
362003-83-6
DESCRIPTION [362003-83-6]
Overview
| MDL | MFCD01988824 |
|---|---|
| Molecular Weight | 431.55 |
| Molecular Formula | C25H25N3O2S |
| SMILES | O=C(C1(C2)CC3CC2CC(C3)C1)NC4=CC=C5N=C(NC(C6=CC=CC=C6)=O)SC5=C4 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3172 mL | 11.5861 mL | 23.1723 mL |
| 5 mM | 0.4634 mL | 2.3172 mL | 4.6345 mL |
| 10 mM | 0.2317 mL | 1.1586 mL | 2.3172 mL |
| 50 mM | 0.0463 mL | 0.2317 mL | 0.4634 mL |
Description
NVP 231 is a novel inhibitor that inhibits the catalytic activity of recombinant CerK in vitro with an IC50 of 12 nM. NVP 231 induces cell apoptosis by increasing DNA fragmentation and .
Targets
| CreK [1] (Cell-free assay) |
| 12 nM |
In vitro
NVP-231 reduces cell viability and DNA synthesis by triggering cell death of cancer cells. NVP-231-treated cells committed M phase arrest rather than arrest at the G2/M boundary. In MCF-7 and NCI-H358 cells, NVP-231 treatment causes a concentration-dependent up-regulation of cyclin B1 phosphorylation at Ser133 and a reduction of CDK1 phosphorylation at Tyr15. Wee1 is down-regulated by NVP-231 in both NCI-H358 and MCF-7 cells. Upon NVP-231 treatment of cancer cells, CDK4 protein is concentration- and time-dependently down-regulated. This effect is even more pronounced in synchronized cells.
References
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