[CAS NO. 1453208-66-6] ASP5878
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PRODUCTS SPECIFICATIONS [1453208-66-6]
Store
Catalog
SLK-S6539
Brand
Selleck
CAS
1453208-66-6
DESCRIPTION [1453208-66-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 407.37 |
| Molecular Formula | C18H19F2N5O4 |
| SMILES | COC1=CC(OC)=C(F)C(COC2=CN=C(NC3=CN(CCO)N=C3)N=C2)=C1F |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4548 mL | 12.2739 mL | 24.5477 mL |
| 5 mM | 0.4910 mL | 2.4548 mL | 4.9095 mL |
| 10 mM | 0.2455 mL | 1.2274 mL | 2.4548 mL |
| 50 mM | 0.0491 mL | 0.2455 mL | 0.4910 mL |
Description
ASP5878 is a novel -selective inhibitor with IC50 values of 0.47, 0.60, 0.74, and 3.5 nmol/L for recombinant FGFR1, 2, 3, and 4, respectively.
Targets
In vitro
ASP5878 inhibits the cell proliferation of HCC cell lines expressing FGF19. ASP5878 inhibits FGFR4 phosphorylation and its treatment results in the suppression of phosphorylation, mobility shift of FRS2, and suppression of ERK phosphorylation in Hep3B2.1-7 cells.
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