[CAS NO. 1532593-30-8] ML355
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PRODUCTS SPECIFICATIONS [1532593-30-8]
Store
Catalog
SLK-S6557
Brand
Selleck
CAS
1532593-30-8
DESCRIPTION [1532593-30-8]
Overview
| MDL | MFCD28167822 |
|---|---|
| Molecular Weight | 441.52 |
| Molecular Formula | C21H19N3O4S2 |
| SMILES | O=S(NC1=NC2=CC=CC=C2S1)(C3=CC=C(NCC4=CC=CC(OC)=C4O)C=C3)=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2649 mL | 11.3245 mL | 22.6490 mL |
| 5 mM | 0.4530 mL | 2.2649 mL | 4.5298 mL |
| 10 mM | 0.2265 mL | 1.1325 mL | 2.2649 mL |
| 50 mM | 0.0453 mL | 0.2265 mL | 0.4530 mL |
Description
ML355 is a potent and selective inhibitor of with an IC50 of 290 nM and shows excellent selectivity over related lipoxygenases and cyclooxygenases.
Targets
| 12-LOX [1] |
In vitro
ML355 displays nM potency against 12-LOX and excellent selectivity over related lipoxygenases and cyclooxygenases.
References
[1] Luci D, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-2013 Apr 12 [updated 2014 Sep 18].
[2] Yang X, et al. Oncogenesis. 2021 Feb 12;10(2):15.
[3] Adili R, et al. Arterioscler Thromb Vasc Biol. 2017 Oct;37(10):1828-1839.
[2] Yang X, et al. Oncogenesis. 2021 Feb 12;10(2):15.
[3] Adili R, et al. Arterioscler Thromb Vasc Biol. 2017 Oct;37(10):1828-1839.
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