[CAS NO. 155798-08-6] 4-IBP

Name: 4-IBP
Brand: Arctom Scientific
SKU: SLK-S6561

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PRODUCTS SPECIFICATIONS [155798-08-6]

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Catalog

SLK-S6561

Brand

Selleck

CAS

155798-08-6

DESCRIPTION [155798-08-6]

Overview

MDL	MFCD00673910
Molecular Weight	420.29
Molecular Formula	C19H21IN2O
SMILES	O=C(NC1CCN(CC2=CC=CC=C2)CC1)C3=CC=C(I)C=C3

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.3793 mL	11.8965 mL	23.7931 mL
5 mM	0.4759 mL	2.3793 mL	4.7586 mL
10 mM	0.2379 mL	1.1897 mL	2.3793 mL
50 mM	0.0476 mL	0.2379 mL	0.4759 mL

Description

4-IBP is a selective agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM).

Targets

σ1 receptor ^[1]	σ2 receptor ^[1]
1.7 nM(Ki)	25.2 nM(Ki)

In vitro

4-IBP decreases the migration levels of various types of cancer cells, including C32 melanoma, U373-MG glioblastoma, A549 NSCLC, and PC3 prostate cancer cells. 4-IBP modifies the sensitivity of U373-MG cells in vitro to proapoptotic lomustin and proautophagic temozolomide, and markedly decreases the expression of two proteins involved in drug resistance: glucosylceramide synthase and Rho guanine nucleotide dissociation inhibitor.

References

[1] Mégalizzi V, et al. Neoplasia. 2007, 9(5):358-69.