[CAS NO. 899713-86-1] ML348
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PRODUCTS SPECIFICATIONS [899713-86-1]
Store
Catalog
SLK-S6564
Brand
Selleck
CAS
899713-86-1
DESCRIPTION [899713-86-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 415.79 |
| Molecular Formula | C18H17ClF3N3O3 |
| SMILES | O=C(NC1=CC(C(F)(F)F)=CC=C1Cl)CN2CCN(C(C3=CC=CO3)=O)CC2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4051 mL | 12.0253 mL | 24.0506 mL |
| 5 mM | 0.4810 mL | 2.4051 mL | 4.8101 mL |
| 10 mM | 0.2405 mL | 1.2025 mL | 2.4051 mL |
| 50 mM | 0.0481 mL | 0.2405 mL | 0.4810 mL |
Description
ML348 (GNF-Pf-1127) is a potent and selective inhibitor with Ki values of 280 nM and >10 μM for APT1 and APT2, respectively.
Targets
| APT1 [1] |
| 280 nM(Ki) |
In vitro
ML348 increases brain palmitoylation and inhibits the palmitate-removing enzyme acyl-protein thioesterase 1 (APT1), restores axonal transport, synapse homeostasis, and survival signaling to wild-type levels without toxicity, also increases BDNF trafficking in human HD induced pluripotent stem cell-derived cortical neurons.
References
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