[CAS NO. 1474110-21-8] GSK2981278
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PRODUCTS SPECIFICATIONS [1474110-21-8]
Store
Catalog
SLK-S6610
Brand
Selleck
CAS
1474110-21-8
DESCRIPTION [1474110-21-8]
Overview
| MDL | MFCD29059455 |
|---|---|
| Molecular Weight | 461.61 |
| Molecular Formula | C25H35NO5S |
| SMILES | CC(C)CN(S(=O)(C1=CC=C(OCC2CCOCC2)C(CO)=C1)=O)C3=CC=C(CC)C=C3 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1663 mL | 10.8317 mL | 21.6633 mL |
| 5 mM | 0.4333 mL | 2.1663 mL | 4.3327 mL |
| 10 mM | 0.2166 mL | 1.0832 mL | 2.1663 mL |
| 50 mM | 0.0433 mL | 0.2166 mL | 0.4333 mL |
Description
GSK2981278 is a highly potent and selective inverse agonist for .
Targets
| RORγ [1] |
In vitro
GSK2981278 has no significant effect on RORα-dependent activation. GSK2981278 significantly inhibits production of the Th17 signature (IL-17A, IL-17F, IL-22 and IL-23) in multiple in vitro and human tissue-based assays.
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