[CAS NO. 897657-95-3] MSX-122
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PRODUCTS SPECIFICATIONS [897657-95-3]
Store
Catalog
SLK-S6617
Brand
Selleck
CAS
897657-95-3
DESCRIPTION [897657-95-3]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 292.34 |
| Molecular Formula | C16H16N6 |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.4207 mL | 17.1034 mL | 34.2067 mL |
| 5 mM | 0.6841 mL | 3.4207 mL | 6.8413 mL |
| 10 mM | 0.3421 mL | 1.7103 mL | 3.4207 mL |
| 50 mM | - | - | - |
Description
MSX-122 (Q-122) is a novel small molecule and partial antagonist (IC50~10 nM).
Targets
| CXCR4 [1] |
| ~10 nM |
In vitro
MSX-122 is also incapable of blocking the binding of 125I-labeled CXCL12 to CXCR4. MSX-122 appears to be insufficiently large to block all binding sites between CXCR4 and CXCL12. MSX-122 blocks certain CXCR4 functions via binding to the CXCL12-binding site and interfering with CXCR4/CXCL12-mediated signaling. MSX-122 can intervene in the Gαi-signaling pathway (cAMP modulation), but not the Gq-pathway (calcium flux).
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