[CAS NO. 954126-98-8] Danirixin (GSK1325756)
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PRODUCTS SPECIFICATIONS [954126-98-8]
Store
Catalog
SLK-S6620
Brand
Selleck
CAS
954126-98-8
DESCRIPTION [954126-98-8]
Overview
| MDL | MFCD27987922 |
|---|---|
| Molecular Weight | 441.90 |
| Molecular Formula | C19H21ClFN3O4S |
| SMILES | O=C(NC1=CC=C(Cl)C(S([C@H]2CCCNC2)(=O)=O)=C1O)NC3=C(C)C(F)=CC=C3 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2630 mL | 11.3148 mL | 22.6296 mL |
| 5 mM | 0.4526 mL | 2.2630 mL | 4.5259 mL |
| 10 mM | 0.2263 mL | 1.1315 mL | 2.2630 mL |
| 50 mM | 0.0453 mL | 0.2263 mL | 0.4526 mL |
Description
Danirixin (GSK1325756) is a small molecule, non-peptide, high affinity (IC50 for binding = 12.5 nM), selective, and reversible antagonist.
In vitro
Danirixin has high affinity for CXCR2, with a negative log of the 50% inhibitory concentration (pIC50) of 7.9 for binding to Chinese hamster ovary cell (CHO)-expressed human CXCR2, and 78-fold selectivity over binding to CHO-expressed CXCR1. Danirixin is a competitive antagonist against CXCL8 in Ca2+-mobilization assays, with a K of 6.5 nM and antagonist potency (pA2) of 8.44 and is fully reversible in washout experiments over 180 minutes.
References
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