[CAS NO. 96187-53-0] Brequinar (DUP785)

Name: Brequinar (DUP785)
Brand: Arctom Scientific
SKU: SLK-S6626

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PRODUCTS SPECIFICATIONS [96187-53-0]

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Catalog

SLK-S6626

Brand

Selleck

CAS

96187-53-0

DESCRIPTION [96187-53-0]

Overview

MDL	MFCD00866437
Molecular Weight	375.37
Molecular Formula	C23H15F2NO2
SMILES	CC=1C(=NC2=C(C1C(O)=O)C=C(F)C=C2)C3=CC=C(C=C3)C4=C(F)C=CC=C4

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.6640 mL	13.3202 mL	26.6404 mL
5 mM	0.5328 mL	2.6640 mL	5.3281 mL
10 mM	0.2664 mL	1.3320 mL	2.6640 mL
50 mM	0.0533 mL	0.2664 mL	0.5328 mL

Description

Brequinar (DUP785, NSC 368390) is an inhibitor of with an IC50 of ∼20 nM in vitro.

Targets

DHODH ^[1]

20 nM

In vitro

Brequinar sodium (BQR) reduces of PyN levels in Con A-stimulated T cells and inhibition of cell proliferation at low concentrations, which can be reversed by uridine. However, uridine is unable to reverse the effects of high concentrations of BQR. BQR possesses the ability of inhibiting tyrosine phosphorylation.

References

[1] Sykes DB, et al. Cell. 2016, 167(1):171-186.e15.
[2] Xu X, et al. J Immunol. 1998 Jan 15;160(2):846-53.

Synonyms

4-Quinolinecarboxylic acid, 6-fluoro-2-(2′-fluoro[1,1′-biphenyl]-4-yl)-3-methyl-

6-Fluoro-2-(2′-fluoro[1,1′-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid

Brequinar

Biphenquinate

BPQ