[CAS NO. 1333210-07-3] SAR7334
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PRODUCTS SPECIFICATIONS [1333210-07-3]
Store
Catalog
SLK-S6634
Brand
Selleck
CAS
1333210-07-3
DESCRIPTION [1333210-07-3]
Overview
| MDL | MFCD27992059 |
|---|---|
| Molecular Weight | 367.87 |
| Molecular Formula | C21H22ClN3O |
| SMILES | N#CC1=CC=C(O[C@H]2[C@H](N3C[C@H](N)CCC3)CC4=C2C=CC=C4)C(Cl)=C1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7184 mL | 13.5918 mL | 27.1835 mL |
| 5 mM | 0.5437 mL | 2.7184 mL | 5.4367 mL |
| 10 mM | 0.2718 mL | 1.3592 mL | 2.7184 mL |
| 50 mM | 0.0544 mL | 0.2718 mL | 0.5437 mL |
Description
SAR7334 is a novel, highly potent and bioavailable inhibitor of channels.SAR7334 blocks TRPC6 currents with an IC50 of 7.9 nM in patch-clamp experiment.
Targets
| TPRC6 [1] (Cell-free assay) |
| 7.9nM |
In vitro
SAR7334 inhibits TRPC6, TRPC3 and TRPC7-mediated Ca(2+) influx into cells with IC50s of 9.5, 282 and 226 nM, whereas TRPC4 and TRPC5-mediated Ca(2+) entry was not affected..SAR7334 suppresses TRPC6-dependent acute HPV in isolated perfused lungs from mice.
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