[CAS NO. 878385-84-3] AZD5069
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PRODUCTS SPECIFICATIONS [878385-84-3]
Store
Catalog
SLK-S6645
Brand
Selleck
CAS
878385-84-3
DESCRIPTION [878385-84-3]
Overview
| MDL | MFCD19443645 |
|---|---|
| Molecular Weight | 476.52 |
| Molecular Formula | C18H22F2N4O5S2 |
| SMILES | O=S(N1CCC1)(NC2=NC(SCC3=CC=CC(F)=C3F)=NC(O[C@H](C)[C@@H](O)CO)=C2)=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.0985 mL | 10.4927 mL | 20.9855 mL |
| 5 mM | 0.4197 mL | 2.0985 mL | 4.1971 mL |
| 10 mM | 0.2099 mL | 1.0493 mL | 2.0985 mL |
| 50 mM | 0.0420 mL | 0.2099 mL | 0.4197 mL |
Description
AZD5069 is a novel antagonist of , which is shown to inhibit binding of CXCL8 to CXCR2 with a pIC50 value of 8.8 and inhibit CXCL8 binding to CXCR1 with pIC50 values of 6.5.
Targets
| CXCR2 [1] |
In vitro
AZD5069 is a slowly reversible antagonist of CXCR2 with effects of time and temperature evident on the pharmacology and binding kinetics.
References
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