[CAS NO. 1191385-19-9] B-Raf inhibitor 1 (Compound 13) dihydrochloride

Name: B-Raf inhibitor 1 (Compound 13) dihydrochloride
Brand: Arctom Scientific
SKU: SLK-S6660

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PRODUCTS SPECIFICATIONS [1191385-19-9]

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Catalog

SLK-S6660

Brand

Selleck

CAS

1191385-19-9

DESCRIPTION [1191385-19-9]

Overview

MDL	MFCD18782676
Molecular Weight	551.86
Molecular Formula	C26H21Cl3N8
SMILES	CC1=C(NC2=NC=CC=C2C3=C4N=CNC4=NC=N3)C5=C(C(NC6=CC=C(Cl)C=C6)=NC=C5)C=C1.[H]Cl.[H]Cl

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

B-Raf inhibitor 1 (Compound 13) is a type IIA inhibitor which bind to the DFG-out conformation with ki of 1 nM,1 nM,and 0.3 nM for B-Raf(WT), B-Raf(V600E) and C-Raf, respectively.

Targets

C-Raf ^[1] (Cell-free assay)	B-Raf(WT) ^[1] (Cell-free assay)	B-Raf(V600E) ^[1] (Cell-free assay)
0.3 nM(Ki)	1 nM(Ki)	1 nM(Ki)

References

[1] Wang X,J Med Chem. 2012 13;55(17):7332-41. Kim J.