[CAS NO. 1301214-47-0] PF-05175157
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PRODUCTS SPECIFICATIONS [1301214-47-0]
Store
Catalog
SLK-S6672
Brand
Selleck
CAS
1301214-47-0
DESCRIPTION [1301214-47-0]
Overview
| MDL | MFCD28502250 |
|---|---|
| Molecular Weight | 405.49 |
| Molecular Formula | C23H27N5O2 |
| SMILES | O=C1CC2(CCN(C(C3=CC=C4C(NC(C)=N4)=C3)=O)CC2)CC5=C1N(C(C)C)N=C5 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4662 mL | 12.3308 mL | 24.6615 mL |
| 5 mM | 0.4932 mL | 2.4662 mL | 4.9323 mL |
| 10 mM | 0.2466 mL | 1.2331 mL | 2.4662 mL |
| 50 mM | 0.0493 mL | 0.2466 mL | 0.4932 mL |
Description
PF-05175157 is a broad-spectrum effective inhibitor with IC50 of 27.0 nM, 33.0 nM, 23.5 nM and 50.4 nM for human ACC1, human ACC2, rat ACC1, and rat ACC2, respectively.
Targets
In vitro
The in vitro metabolism of PF-05175157 is evaluated in microsomes from rat, dog, and human hepatocytes. PF-05175157 is not metabolized in rat, dog, or human microsomes. PF-05175157 is also stable in human hepatocyte incubations, but is minimally metabolized by recombinant human CYP3A4 and CYP3A5, suggesting it is a substrate for CYP3A4 and CYP3A5. PF-05175157 inhibits formation of malonyl-CoA in a concentration-dependent manner with a potency (EC50 = 30 nM) in rat hepatocytes consistent with its potency against rat ACC1 (24 nM).
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