[CAS NO. 303727-31-3]  L-779450

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PRODUCTS SPECIFICATIONS [303727-31-3]

Store
Catalog
SLK-S6680
Brand
Selleck
CAS
303727-31-3

DESCRIPTION [303727-31-3]

Overview

MDLMFCD12828750
Molecular Weight347.80
Molecular FormulaC20H14ClN3O
SMILESOC1=CC(C2=C(C3=CC=NC=C3)NC(C4=CC=CC=C4)=N2)=CC=C1Cl

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

1 mg5 mg10 mg
1 mM2.8752 mL14.3761 mL28.7522 mL
5 mM0.5750 mL2.8752 mL5.7504 mL
10 mM0.2875 mL1.4376 mL2.8752 mL
50 mM0.0575 mL0.2875 mL0.5750 mL

Description

L-779450 is a highly potent low nanomolar inhibitor of with IC50 of 10 nM and Kd of 2.4 nM.

Targets

B-Raf [1]
(Cell-free assay)
B-Raf [1]
(Cell-free assay)
2.4 nM(Kd)10 nM

In vitro

L-779450 shows the generally good selectivity profile against a panel of 21 protein kinases..