[CAS NO. 2267329-76-8] TQB3804 (EGFR-IN-7)

Name: TQB3804 (EGFR-IN-7)
Brand: Arctom Scientific
SKU: SLK-S6698

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PRODUCTS SPECIFICATIONS [2267329-76-8]

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Catalog

SLK-S6698

Brand

Selleck

CAS

2267329-76-8

DESCRIPTION [2267329-76-8]

Overview

MDL	-
Molecular Weight	694.60
Molecular Formula	C32H41BrN9O2P
SMILES	CN1CCN(C2CCN(C3=C(C)C=C(NC4=NC=C(Br)C(NC5=CC=C6N=CC=NC6=C5P(C)(C)=O)=N4)C(OC)=C3)CC2)CC1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.4397 mL	7.1984 mL	14.3968 mL
5 mM	-	-	-
10 mM	-	-	-
50 mM	-	-	-

Description

TQB3804 (EGFR-IN-7) is a selective and potent kinase inhibitor with IC50 of 0.46 nM, 0.13 nM, 0.26 nM, 0.19 nM and 1.07 nM for for EGFR, EGFR, EGFR, EGFR and EGFR, respectively. TQB3804 (EGFR-IN-7) shows anti-tumor activity.

Targets

EGFR^{L858R/T790M/C797S} ^[1] (Cell-free assay)	EGFR^L858R/T790M ^[1] (Cell-free assay)	EGFR^{d746-750/T790M} ^[1] (Cell-free assay)	EGFR^{d746-750/T790M/C797S} ^[1] (Cell-free assay)	EGFR^WT ^[1] (Cell-free assay)
0.13 nM	0.19 nM	0.26 nM	0.46 nM	1.07 nM

References

[1] Xile Liu, et al. Cancer Res 2019;79(13 Suppl):Abstract nr 1320.