[CAS NO. 937039-45-7] TC-H 106

Name: TC-H 106
Brand: Arctom Scientific
SKU: SLK-S6738

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [937039-45-7]

Store

Catalog

SLK-S6738

Brand

Selleck

CAS

937039-45-7

DESCRIPTION [937039-45-7]

Overview

MDL	MFCD17010287
Molecular Weight	339.43
Molecular Formula	C20H25N3O2
SMILES	O=C(NC1=CC=CC=C1N)CCCCCC(NC2=CC=C(C)C=C2)=O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.9461 mL	14.7306 mL	29.4612 mL
5 mM	0.5892 mL	2.9461 mL	5.8922 mL
10 mM	0.2946 mL	1.4731 mL	2.9461 mL
50 mM	0.0589 mL	0.2946 mL	0.5892 mL

Description

TC-H 106 (Pimelic Diphenylamide 106) is a slow, tight-binding inhibitor of class I with Ki value of 148 nM, about 102 nM, 14 nM for , , , respectively.

Targets

HDAC3 ^[1] (Cell-free assay)	HDAC2 ^[1] (Cell-free assay)	HDAC1 ^[1] (Cell-free assay)
14 nM(Ki)	~102 nM(Ki)	148 nM(Ki)

In vitro

The ability of TC-H 106 to prolong histone acetylation has also been observed in cell culture. Cells treated with TC-H 106 (at a sub-EC10 concentration as determined with an MTS cell proliferation assay) have hyperacetylated histone H3. These cells do not lose significant amounts of acetylated histone H3 even after removal of the inhibitor for hours..

References

[1] Chou CJ, et al. J Biol Chem. 2008 19;283(51):35402-9.