[CAS NO. 309271-94-1] Inauhzin

Name: Inauhzin
Brand: Arctom Scientific
SKU: SLK-S6744

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PRODUCTS SPECIFICATIONS [309271-94-1]

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Catalog

SLK-S6744

Brand

Selleck

CAS

309271-94-1

DESCRIPTION [309271-94-1]

Overview

MDL	-
Molecular Weight	469.58
Molecular Formula	C25H19N5OS2
SMILES	CCC(SC1=NN=C2C(NC3=C2C=CC=C3)=N1)C(N4C5=C(C=CC=C5)SC6=CC=CC=C46)=O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.1296 mL	10.6478 mL	21.2956 mL
5 mM	0.4259 mL	2.1296 mL	4.2591 mL
10 mM	0.2130 mL	1.0648 mL	2.1296 mL
50 mM	0.0426 mL	0.2130 mL	0.4259 mL

Description

Inauhzin is a cell-permeable inhibitor with an IC50 of 0.7-2 μM and reactivates by inhibiting SIRT1 deacetylation activity.

Targets

SIRT1 ^[2]

p53 ^[1]

In vitro

Inauhzin (INZ) is a potent p53 activator and mediates p53-dependent cytotoxicity. INZ inhibits cell proliferation by triggering both apoptosis and senescence in p53-containning cells, though it predominantly induces p53-dependent apoptosis. INZ is able to prevent p53 from MDM2-mediated ubiquitylation and proteasomal degradation and protects p53 without either directly inhibiting MDM2 activity towards p53 or interfering with MDMX/MDM2–p53 interaction. INZ induces acetylation of p53, but not tubulin, in cells. Inauhzin is a (sub)micromolar SIRT1i selective over SIRT2/3.

References

[1] Zhang Q, et al. EMBO Mol Med. 2012, 4(4):298-312.
[2] Carafa V, et al. Clin Epigenetics. 2016, 8:61.