[CAS NO. 93718-83-3] NSC95397

Name: NSC95397
Brand: Arctom Scientific
SKU: SLK-S6777

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PRODUCTS SPECIFICATIONS [93718-83-3]

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Catalog

SLK-S6777

Brand

Selleck

CAS

93718-83-3

DESCRIPTION [93718-83-3]

Overview

MDL	-
Molecular Weight	310.39
Molecular Formula	C14H14O4S2
SMILES	O=C1C=2C(C(=O)C(SCCO)=C1SCCO)=CC=CC2

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

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Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.2218 mL	16.1088 mL	32.2175 mL
5 mM	0.6444 mL	3.2218 mL	6.4435 mL
10 mM	0.3222 mL	1.6109 mL	3.2218 mL
50 mM	0.0644 mL	0.3222 mL	0.6444 mL

Description

NSC 95397 is a potent, selective dual specificity phosphatase inhibitor with Ki of 32 nM, 96 nM, 40 nM for Cdc25A, Cdc25B and Cdc25C, respectively. NSC 95397 has IC50 of 22.3 nM, 56.9 nM and 125 nM for human Cdc25A, human Cdc25C and Cdc25B, respectively. NSC 95397 inhibits and suppresses proliferation and induces apoptosis in colon cancer cells through MKP-1 and ERK1/2 pathway.

Targets

References

[1] Lazo JS, et al. Mol Pharmacol. 2002 Apr;61(4):720-8.
[2] Dubey NK, et al.Int J Mol Sci. 2018 May 31;19(6).

Synonyms

1,4-Naphthalenedione, 2,3-bis[(2-hydroxyethyl)thio]-

1,4-Naphthoquinone, 2,3-bis[(2-hydroxyethyl)thio]-

2,3-Bis[(2-hydroxyethyl)thio]-1,4-naphthalenedione

NSC 95397

2,3-Bis(2-hydroxyethylthio)-1,4-naphthalenedione

2,3-Bis(2-hydroxyethylsulfanyl)naphthalene-1,4-dione