[CAS NO. 1093070-16-6]  GRL0617

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PRODUCTS SPECIFICATIONS [1093070-16-6]

Store
Catalog
SLK-S6845
Brand
Selleck
CAS
1093070-16-6

DESCRIPTION [1093070-16-6]

Overview

MDLMFCD12547683
Molecular Weight304.39
Molecular FormulaC20H20N2O
SMILESO=C(N[C@@H](C1=C2C=CC=CC2=CC=C1)C)C3=CC(N)=CC=C3C

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

1 mg5 mg10 mg
1 mM3.2853 mL16.4263 mL32.8526 mL
5 mM0.6571 mL3.2853 mL6.5705 mL
10 mM0.3285 mL1.6426 mL3.2853 mL
50 mM0.0657 mL0.3285 mL0.6571 mL

Description

GRL0617 is a potent, selective and competitive noncovalent inhibitor of severe acute respiratory syndrome (SARS-CoV) with IC50 of 0.6 μM and Ki of 0.49 μM. GRL0617 inhibits SARS-CoV viral replication in Vero E6 cells with EC50 of 15 microM and has no associated cytotoxicity.

Targets

PLPro/deubiquitinase [1]
(Cell-free assay)
PLPro/deubiquitinase [1]
(Cell-free assay)
0.49 μM(Ki)0.6 μM