[CAS NO. 25526-93-6] 3'-Fluoro-3'-deoxythymidine (Alovudine)

Name: 3'-Fluoro-3'-deoxythymidine (Alovudine)
Brand: Arctom Scientific
SKU: SLK-S6848

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PRODUCTS SPECIFICATIONS [25526-93-6]

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Catalog

SLK-S6848

Brand

Selleck

CAS

25526-93-6

DESCRIPTION [25526-93-6]

Overview

MDL	MFCD00056058
Molecular Weight	244.22
Molecular Formula	C10H13FN2O4
SMILES	O=C1N([C@@]2(O[C@H](CO)[C@@H](F)C2)[H])C=C(C)C(=O)N1

For research use only.

Storage

3 years -20°C(in the dark) powder
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	4.0947 mL	20.4733 mL	40.9467 mL
5 mM	0.8189 mL	4.0947 mL	8.1893 mL
10 mM	0.4095 mL	2.0473 mL	4.0947 mL
50 mM	0.0819 mL	0.4095 mL	0.8189 mL

Description

3'-Fluoro-3'-deoxythymidine (Alovudine, CL 184824, FddThd, FLT, MIV-310) is a potent inhibitor of and that can be used in the treatment of HIV infection. 3'-Fluoro-3'-deoxythymidine (Alovudine) is also a marker of that can be used as an early response biomarker in the chemotherapy of pancreatic cancer.

Targets

polymerase γ ^[3]

Reverse transcriptase ^[2]

References

[1] Amarnath Challapalli, et al. Eur J Nucl Med Mol Imaging. 2015 May;42(6):831-40.
[2] J Ghosn, et al. HIV Med. 2007 Apr;8(3):142-7.
[3] Dana Yehudai, et al. Haematologica. 2019 May;104(5):963-972. `

Synonyms

Thymidine, 3′-deoxy-3′-fluoro-

3′-Deoxy-3′-fluorothymidine

1-(3′-Deoxy-3′-fluoro-β-D-pentofuranosyl)thymine

3′-Fluorodeoxythymidine

3′-Fluorothymidine

3′-Fluoro-3′-deoxythymidine

FLT

Alovudine

CL 184824

NSC 140025

MIV 310

3′-Fluoro-2′,3′-dideoxythymidine