[CAS NO. 129-16-8] Merbromin
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PRODUCTS SPECIFICATIONS [129-16-8]
Store
Catalog
SLK-S6872
Brand
Selleck
CAS
129-16-8
DESCRIPTION [129-16-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 752.68 |
| Molecular Formula | C20H10Br2HgO6.2Na |
| SMILES | O=C1OC2(C=3C(OC=4C2=CC(Br)=C(O)C4)=C([Hg]O)C(O)=C(Br)C3)C=5C1=CC=CC5.[Na] |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.3286 mL | 6.6429 mL | 13.2859 mL |
| 5 mM | 0.2657 mL | 1.3286 mL | 2.6572 mL |
| 10 mM | 0.1329 mL | 0.6643 mL | 1.3286 mL |
| 50 mM | 0.0266 mL | 0.1329 mL | 0.2657 mL |
Description
Merbromin (Mercurochrome), a xanthene dye and an agent, is the first of a series of antiseptics that contained mercury, also is a mixed-type inhibitor of due to its ability of increasing the K and decreasing the K of 3CLpro.
Targets
| 3C-Like Protease [1] |
In vitro
Merbromin strongly inhibites the proteolytic activity of 3CLpro which is a promising target for developing anti-SARS-CoV-2 drugs. Michaelis-Menten kinetic analysis shows that Merbromin is a mixed-type inhibitor of 3CLpro, indicating by its ability of increasing the KM and decreasing the Kcat of 3CLpro. And 3CLpro possessed two binding sites for Merbromin.
References
Synonyms
Mercury, (2′,7′-dibromo-3′,6′-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9′-[9H]xanthen]-4′-yl)hydroxy-, sodium salt (1:2)
Mercury, [2,7-dibromo-9-(o-carboxyphenyl)-6-hydroxy-3-oxo-3H-xanthen-4-yl]hydroxy-, disodium salt
Mercury, (2′,7′-dibromo-3′,6′-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9′-[9H]xanthen]-4′-yl)hydroxy-, disodium salt
Fluorescein, 2′,7′-dibromo-4′-(hydroxymercuri)-, disodium salt
Spiro[isobenzofuran-1(3H),9′-[9H]xanthen]-3-one, 2′,7′-dibromo-3′,6′-dihydroxy-, mercury complex
Spiro[isobenzofuran-1(3H),9′-[9H]xanthene], mercury deriv.
Asceptichrome
Aseptichrome
Chromargyre
2,7-Dibromo-4-hydroxymercurifluoresceine disodium salt
Disodium 2′,7′-dibromo-4′-(hydroxymercury)fluorescein
DOMF
Flavurol
Fluorochrome
Gallochrome
Gynochrome
Merbromin
Mercuranine
Mercurochrome
Mercurocol
Mercurome
Mercurophage
No. 220 Soluble
Planochrome
Disodium 2,7-dibromo-4-(hydroxymercuri)fluorescein
Sodium 2,7-dibromo-4-hydroxymercurifluorescein
Mercurichrome
Mercuresceine
Curichrome
Curocromo
Cynochrome
Brocasept
Lapicromo
Lafircrom
Emcerol
Mercromina film
Supercromer orto
Cinfacromin
Sodium mercurescein
No. 220 sol
Mercurochrome 220 Soluble
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