[CAS NO. 307510-92-5] CFTRinh-172

Name: CFTRinh-172
Brand: Arctom Scientific
SKU: SLK-S7139

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PRODUCTS SPECIFICATIONS [307510-92-5]

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Catalog

SLK-S7139

Brand

Selleck

CAS

307510-92-5

DESCRIPTION [307510-92-5]

Overview

MDL	MFCD01164609
Molecular Weight	409.4
Molecular Formula	C18H10F3NO3S2
SMILES	O=C1N(C(=S)SC1=CC2=CC=C(C(O)=O)C=C2)C3=CC(C(F)(F)F)=CC=C3

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.4426 mL	12.2130 mL	24.4260 mL
5 mM	0.4885 mL	2.4426 mL	4.8852 mL
10 mM	0.2443 mL	1.2213 mL	2.4426 mL
50 mM	0.0489 mL	0.2443 mL	0.4885 mL

Description

CFTRinh-172 (CFTR inhibitor 172) is a voltage-independent, selective inhibitor with of 300 nM, showing no effects on MDR1, ATP-sensitive K+ channels, or a series of other transporters.

Targets

CFTR ^[1]
(in human airway cells)

300 nM(Ki)

In vitro

CFTRinh-172 dose- and time-dependently inhibits CFTR-mediated I transportation, and effectively inhibits CFTR activation by multiple types of agonists or activators. CFTRinh-172, as a selective CFTR channel inhibitor, also completely abolishes the Cl current in the rabbit acinar and duct cells of rabbit lacrimal gland. CFTRinh-172 also induces ROS production, mitochondrial failure, and activation of the NF-κB signaling pathway, independently of CFTR inhibition.

In vivo

CFTRinh-172 (20 µg/6 h) completely abolishes the V. cholerae-induced intestinal fluid secretion without affecting V. cholerae growth in vivo.

References

[1] Ma T, et al. J Clin Invest. 2002, 110(11), 1651-1658.
[2] Lu M, et al. Curr Eye Res. 2012, 37(8), 671-677.
[3] Kelly M, et al. J Pharmacol Exp Ther. 2010, 333(1), 60-69.
[4] Sawasvirojwong S, et al. PLoS Negl Trop Dis. 2013, 7(6), e2293.

Synonyms

Benzoic acid, 4-[[4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]-

4-[[4-Oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]benzoic acid

3-[(3-Trifluoromethyl)phenyl]-5-[(4-carboxyphenyl)methylene]-2-thioxo-4-thiazolidinone

Cystic fibrosis transmembrane conductance regulator inhibitor CFTR(inh)-172

CFTR(inh)-172