[CAS NO. 71555-25-4] NSC 319726
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PRODUCTS SPECIFICATIONS [71555-25-4]
Store
Catalog
SLK-S7149
Brand
Selleck
CAS
71555-25-4
DESCRIPTION [71555-25-4]
Overview
| MDL | MFCD01665446 |
|---|---|
| Molecular Weight | 234.32 |
| Molecular Formula | C11H14N4S |
| SMILES | C(=NNC(=S)N1CCC1)(C)C2=CC=CC=N2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.2677 mL | 21.3383 mL | 42.6767 mL |
| 5 mM | 0.8535 mL | 4.2677 mL | 8.5353 mL |
| 10 mM | 0.4268 mL | 2.1338 mL | 4.2677 mL |
| 50 mM | 0.0854 mL | 0.4268 mL | 0.8535 mL |
Description
NSC319726 is a mutant reactivator, exhibits growth inhibition in cells expressing mutant p53, with of 8 nM for p53(R175) mutant, shows no inhibition for p53 wild-type cells.
Features
An allele-specific p53 mutant reactivator.
Targets
| p53 (R175) [1] |
| 8 nM |
In vitro
NSC319726 is a p53(R175) mutant reactivator, exhibits growth inhibition in cells expressing mutant p53, with IC50 of 8 nM for p53(R175) mutant, shows no inhibition for p53 wild-type cells, shows 10- to 100-fold selectivity over the other hotspot p53 mutants. NSC319276 induces p53(R175)-mutant-dependent apoptosis. NSC319726 treatment induces a WT-like conformational change in the p53(R175) mutant protein that restores sequence-specific p53 transcription. The activity of NSC319726 depends on the zinc ion chelating properties of the compound as well as redox changes.
In vivo
NSC319726 (5mg/kg, 7days) exhibits greater toxicity for p53(R172H/R172H) mice, with only 30% survival, as compared to 100% survival for p53 and p53 mice. NSC319726 inhibits the growth of TOV112D-p53(R175H) xenografts, but not H460 (p53) and MDAMB468-p53(R273W) xenografts.
Synonyms
1-Azetidinecarbothioic acid, 2-[1-(2-pyridinyl)ethylidene]hydrazide
1-Azetidinecarbothioic acid, [1-(2-pyridinyl)ethylidene]hydrazide
1-Azetidinecarbothioic acid 2-[1-(2-pyridinyl)ethylidene]hydrazide
NSC 319726
ZMC 1
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