[CAS NO. 130370-60-4] Batimastat (BB-94)

Name: Batimastat (BB-94)
Brand: Arctom Scientific
SKU: SLK-S7155

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PRODUCTS SPECIFICATIONS [130370-60-4]

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Catalog

SLK-S7155

Brand

Selleck

CAS

130370-60-4

DESCRIPTION [130370-60-4]

Overview

MDL	MFCD00866533
Molecular Weight	477.64
Molecular Formula	C23H31N3O4S2
SMILES	[C@@H]([C@H](CSC1=CC=CS1)C(NO)=O)(C(N[C@@H](CC2=CC=CC=C2)C(NC)=O)=O)CC(C)C

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.0936 mL	10.4681 mL	20.9363 mL
5 mM	0.4187 mL	2.0936 mL	4.1873 mL
10 mM	0.2094 mL	1.0468 mL	2.0936 mL
50 mM	0.0419 mL	0.2094 mL	0.4187 mL

Description

Batimastat (BB-94) is a potent, broad spectrum inhibitor for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3 with of 3 nM, 4 nM, 4 nM, 6 nM and 20 nM, respectively. Also inhibits the activitity of other metalloproteases, such as ADAM17.

Targets

MMP-1 ^[1]	MMP-2 ^[1]	MMP-9 ^[1]	MMP-7 ^[1]	MMP-3 ^[1]
3 nM	4 nM	4 nM	6 nM	20 nM

In vitro

Batimastat (BB-94) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3 with IC50 of 3 nM, 4 nM, 4 nM, 6 nM and 20 nM, respectively. Batimastat exhibits an unexpected binding geometry, with the thiophene ring deeply inserted into the primary specificity site.

References

[1] Chirivi RG, et al. Int J Cancer, 1994, 58(3), 460-464.
[2] Botos I, et al. PNAS, 1996, 93(7), 2749-2754.
[3] Wang X, et al. Cancer Res, 1994, 54(17), 4726-4728.
[4] Taraboletti G, et al. J Natl Cancer Inst, 1995, 87(4), 293-298.

Synonyms

Butanediamide, N⁴-hydroxy-N¹-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]-, (2R,3S)-

Butanediamide, N⁴-hydroxy-N¹-[2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]-, [2R-[1(S*),2R*,3S*]]-

(2R,3S)-N⁴-Hydroxy-N¹-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]butanediamide

BB 94

Batimastat

(2S,3R)-5-Methyl-3-[[(αS)-α-(methylcarbamoyl)phenethyl]carbamoyl]-2-[(2-thienylthio)methyl]hexanohydroxamic acid