[CAS NO. 142880-36-2] Ilomastat

Name: Ilomastat
Brand: Arctom Scientific
SKU: SLK-S7157

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PRODUCTS SPECIFICATIONS [142880-36-2]

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Catalog

SLK-S7157

Brand

Selleck

CAS

142880-36-2

DESCRIPTION [142880-36-2]

Overview

MDL	MFCD00917040
Molecular Weight	388.46
Molecular Formula	C20H28N4O4
SMILES	C([C@H](NC([C@@H](CC(NO)=O)CC(C)C)=O)C(NC)=O)C=1C=2C(NC1)=CC=CC2

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.5743 mL	12.8713 mL	25.7427 mL
5 mM	0.5149 mL	2.5743 mL	5.1485 mL
10 mM	0.2574 mL	1.2871 mL	2.5743 mL
50 mM	0.0515 mL	0.2574 mL	0.5149 mL

Description

Ilomastat (GM6001, Galardin) is a broad spectrum inhibitor for MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-14, and MMP-26 with K of 0.4 nM, 0.5 nM, 27 nM, 3.7 nM, 0.1 nM, 0.2 nM, 3.6 nM, 13.4 nM, 0.36 nM, respectively.

Targets

In vitro

GM6001 inhibits human skin fibroblast collagenase with K of 0.4 nM when assayed with a synthetic thio ester substrate at pH 6.5, with 50-fold selectivity over two bacterial enzymes, thermolysin and elastase. GM 6001 (0.1 nM - 10 nM) inhibits gelatinase A and gelatinase B produced by T-cells, thus inhibits T-cell homing.

References

[1] Grobelny D, et al. Biochemistry, 1992, 31(31), 7152-7154.
[2] Leppert D, et al. J Immunol,1995, 154(9), 4379-4389.
[3] Schultz GS, et al. Invest Ophthalmol Vis Sci, 1992, 33(12) 3325-3331.
[4] Li C, et al. J Am Coll Cardiol, 2002, 39(11), 1852-1858.
[5] Wang R, et al. Cell Death Discov. 2022 Apr 8;8(1):180.

Synonyms

Butanediamide, N⁴-hydroxy-N¹-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)-, (2R)-

Butanediamide, N⁴-hydroxy-N¹-[1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)-, [S-(R*,S*)]-

(2R)-N⁴-Hydroxy-N¹-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)butanediamide

GM 6001

Galardin

Ilomastat

CS 610

(R)-N1-((S)-3-(1H-indol-3yl)-1-(methylamino)-1-oxopropan-2-yl)-N4-hydroxy-2-isobutylsuccinamide