[CAS NO. 1256493-34-1] Dyngo-4a
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PRODUCTS SPECIFICATIONS [1256493-34-1]
Store
Catalog
SLK-S7163
Brand
Selleck
CAS
1256493-34-1
DESCRIPTION [1256493-34-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 338.31 |
| Molecular Formula | C18H14N2O5 |
| SMILES | O=C(N/N=C/C1=CC(O)=C(O)C=C1O)C2=C(O)C=C3C=CC=CC3=C2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.9559 mL | 14.7793 mL | 29.5587 mL |
| 5 mM | 0.5912 mL | 2.9559 mL | 5.9117 mL |
| 10 mM | 0.2956 mL | 1.4779 mL | 2.9559 mL |
| 50 mM | 0.0591 mL | 0.2956 mL | 0.5912 mL |
Description
Dyngo-4a is a potent inhibitor with of 0.38 μM, 1.1 μM, and 2.3 μM for DynI (brain), DynI (rec), and DynII (rec), respectively.
In vitro
Dyngo-4a inhibits dynamin-dependent endocytosis of transferrin in multiple cell types with IC₅₀ of 5.7 μM, and reduces synaptic vesicle endocytosis and activity-dependent bulk endocytosis in cultured neurons and synaptosomes. In motor nerve terminals and cultured hippocampal neurons, Dyngo-4a blocks Alexa Fluor 488-BoNT/A-Hc internalization. In Drosophila S2R+ cells, Dyngo-4a causes a decrease in the level of Armadillo/β-catenin.
References
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