[CAS NO. 1078166-57-0] PF-04418948
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PRODUCTS SPECIFICATIONS [1078166-57-0]
Store
Catalog
SLK-S7211
Brand
Selleck
CAS
1078166-57-0
DESCRIPTION [1078166-57-0]
Overview
| MDL | MFCD24387541 |
|---|---|
| Molecular Weight | 409.41 |
| Molecular Formula | C23H20FNO5 |
| SMILES | O=C(C1(COC2=CC=C3C=C(OC)C=CC3=C2)CN(C(C4=CC=C(F)C=C4)=O)C1)O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4425 mL | 12.2127 mL | 24.4254 mL |
| 5 mM | 0.4885 mL | 2.4425 mL | 4.8851 mL |
| 10 mM | 0.2443 mL | 1.2213 mL | 2.4425 mL |
| 50 mM | 0.0489 mL | 0.2443 mL | 0.4885 mL |
Description
PF-04418948 is a potent and selective prostaglandin antagonist with of 16 nM. Phase 1.
Targets
| EP₂ receptor [1] |
| 16 nM |
In vitro
PF-04418948 antagonizes the effects of butaprost and PGE2 on an EFS-induced contraction of the human myometrium, and antagonizes PGE2-induced relaxation of carbachol pre-contracted rings of mouse trachea. PF-04418948 competitively inhibits relaxations of murine and guinea pig trachea induced by ONO-AE1-259 and PGE2 respectively. PF-04418948 restores neutrophil extracellular traps (NETs) formation in neutrophils isolated from BMT mice or HSCT patients.
References
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