[CAS NO. 1221485-83-1] Skepinone-L

Name: Skepinone-L
Brand: Arctom Scientific
SKU: SLK-S7214

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PRODUCTS SPECIFICATIONS [1221485-83-1]

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Catalog

SLK-S7214

Brand

Selleck

CAS

1221485-83-1

DESCRIPTION [1221485-83-1]

Overview

MDL	MFCD22572738
Molecular Weight	425.42
Molecular Formula	C24H21F2NO4
SMILES	O=C1C2=CC=C(NC3=CC=C(F)C=C3F)C=C2CCC4=CC=C(OC[C@H](O)CO)C=C14

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.3506 mL	11.7531 mL	23.5062 mL
5 mM	0.4701 mL	2.3506 mL	4.7012 mL
10 mM	0.2351 mL	1.1753 mL	2.3506 mL
50 mM	0.0470 mL	0.2351 mL	0.4701 mL

Description

Skepinone-L (CBS3830) is a selective inhibitor with of 5 nM.

Targets

p38α ^[1]

5 nM

In vitro

Skepinone-L shows concentration-dependent inhibition of HSP27 (Ser82) phosphorylation through the p38 MAPK pathway with a cellular IC50 of approximately 25 nM, and also reduces concentrations of TNF-α, IL-1β and IL-10, regulated by p38 MAPK, with IC50 ranging from 30 to 50 nM . Skepinone-L (1 μM) abrogates the phosphorylation of platelet p38 MAPK substrate Hsp27 activated by stimulation with CRP, thrombin or thromboxane A2 analogue U-46619, and impairs platelet secretion and aggregation.

In vivo

In vivo, skepinone-L inhibits Gal/ LPS-induced TNF-α release by 77%.

References

[1] Koeberle SC, et al. Nat Chem Biol. 2011, 8(2), 141-143.
[2] Borst O, et al. Cell Physiol Biochem. 2013, 31(6), 914-924.