[CAS NO. 585543-15-3] Losmapimod (GW856553X)

Name: Losmapimod (GW856553X)
Brand: Arctom Scientific
SKU: SLK-S7215

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PRODUCTS SPECIFICATIONS [585543-15-3]

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Catalog

SLK-S7215

Brand

Selleck

CAS

585543-15-3

DESCRIPTION [585543-15-3]

Overview

MDL	MFCD16619322
Molecular Weight	383.46
Molecular Formula	C22 H26 F N3 O2
SMILES	CC=1C(=CC(C(NC2CC2)=O)=CC1F)C3=CC=C(C(NCC(C)(C)C)=O)C=N3

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.6078 mL	13.0392 mL	26.0783 mL
5 mM	0.5216 mL	2.6078 mL	5.2157 mL
10 mM	0.2608 mL	1.3039 mL	2.6078 mL
50 mM	0.0522 mL	0.2608 mL	0.5216 mL

Description

Losmapimod (GW856553X, GW856553, GSK-AHAB) is a selective, potent, and orally active inhibitor with of 8.1 and 7.6 for p38α and p38β, respectively. P38 MAPKs are involved in cell differentiation, and . Phase 3.

Targets

p38α ^[1] (Cell-free assay)	p38β ^[1] (Cell-free assay)
8.1(pKi)	7.6(pKi)

In vitro

Losmapimod (GW856553X, GW856553, GSK-AHAB) is a selective, potent, and orally active p38 MAPK inhibitor.

References

[1] Willette RN, et al. J Pharmacol Exp Ther. 2009, 330(3), 964-970.
[2] Brennan CM, et al. Dis Model Mech. 2022 Nov 1;15(11):dmm049516.

Synonyms

3-Pyridinecarboxamide, 6-[5-[(cyclopropylamino)carbonyl]-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)-

6-[5-[(Cyclopropylamino)carbonyl]-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)-3-pyridinecarboxamide

6-[5-(Cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)nicotinamide

GW 856553X

Losmapimod

GSK-AHAB

SB 856553

GW 856553