[CAS NO. 446859-33-2] RepSox (E-616452)
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PRODUCTS SPECIFICATIONS [446859-33-2]
Store
Catalog
SLK-S7223
Brand
Selleck
CAS
446859-33-2
DESCRIPTION [446859-33-2]
Overview
| MDL | MFCD09037561 |
|---|---|
| Molecular Weight | 287.32 |
| Molecular Formula | C17H13N5 |
| SMILES | CC1=CC=CC(=N1)C1=NNC=C1C1=CC=C2N=CC=CC2=N1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.4804 mL | 17.4022 mL | 34.8044 mL |
| 5 mM | 0.6961 mL | 3.4804 mL | 6.9609 mL |
| 10 mM | 0.3480 mL | 1.7402 mL | 3.4804 mL |
| 50 mM | 0.0696 mL | 0.3480 mL | 0.6961 mL |
Description
RepSox (E-616452, SJN 2511, ALK5 Inhibitor II) is a potent and selective inhibitor of the with of 23 nM and 4 nM for ATP binding to ALK5 and ALK5 autophosphorylation in cell-free assays, respectively.
Targets
| TGFβR1(ALK5) [1] (Cell-free assay) |
| 4 nM |
In vitro
RepSox inhibits ATP binding to ALK5 and ALK5 autophosphorylation with IC50 of 23 nM and 4 nM, respectively. RepSox inhibits TGF-β induced cellular PAI-1 luciferase activity with IC50 of 18 nM. RepSox is able to successfully replace Sox2 in reprogramming by inhibiting transforming growth factor-β (Tgf-β) signaling, which in turn induces Nanog expression. Effect of RepSox inducing reprogramming does not require chromatin remodeling. RepSox is found to be efficient at generating iPSCs.
References
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