[CAS NO. 1440898-61-2] Deltarasin
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PRODUCTS SPECIFICATIONS [1440898-61-2]
Store
Catalog
SLK-S7224
Brand
Selleck
CAS
1440898-61-2
DESCRIPTION [1440898-61-2]
Overview
| MDL | MFCD26793865 |
|---|---|
| Molecular Weight | 603.75 |
| Molecular Formula | C40H37N5O |
| SMILES | C1(C2=CC=C(OC[C@@H](N3C4=CC=CC=C4N=C3C5=CC=CC=C5)C6CCNCC6)C=C2)=NC7=CC=CC=C7N1CC8=CC=CC=C8 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.6563 mL | 8.2816 mL | 16.5631 mL |
| 5 mM | 0.3313 mL | 1.6563 mL | 3.3126 mL |
| 10 mM | 0.1656 mL | 0.8282 mL | 1.6563 mL |
| 50 mM | 0.0331 mL | 0.1656 mL | 0.3313 mL |
Description
Deltarasin is a small molecular inhibitor of interaction with of 38 nM for binding to purified PDEδ.
In vitro
In liver cells, Deltarasin inhibits the interaction of RAS with PDEδ with K of 41 nM. Inhibition of PDEδ-KRAS interaction by Deltarasin suppresses proliferation of human pancreatic ductal adenocarcinoma cells that are dependent on oncogenic KRAS.
In vivo
Deltarasin (10 mg/kg i.p.) impairs dose-dependent tumor growth in nude mice bearing subcutaneous human Panc-Tu-I tumour cell xenografts.
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