[CAS NO. 1432660-47-3] AGI-6780
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PRODUCTS SPECIFICATIONS [1432660-47-3]
Store
Catalog
SLK-S7241
Brand
Selleck
CAS
1432660-47-3
DESCRIPTION [1432660-47-3]
Overview
| MDL | MFCD26097285 |
|---|---|
| Molecular Weight | 481.51 |
| Molecular Formula | C21 H18 F3 N3 O3 S2 |
| SMILES | O=S(C1=CC=C(C2=CSC=C2)C(NC(NC3=CC=CC(C(F)(F)F)=C3)=O)=C1)(NC4CC4)=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.0768 mL | 10.3840 mL | 20.7680 mL |
| 5 mM | 0.4154 mL | 2.0768 mL | 4.1536 mL |
| 10 mM | 0.2077 mL | 1.0384 mL | 2.0768 mL |
| 50 mM | 0.0415 mL | 0.2077 mL | 0.4154 mL |
Description
AGI-6780 is a potent and selective inhibitor of with of 23 nM.
Targets
| IDH2 R140Q mutant [1] |
| 23 nM |
In vitro
AGI-6780 potently reduce (R)-2-hydroxyglutarate (2HG) levels in cell lines ectopically overexpressing IDH2/R140Q with EC50 of 20 nM, with excellent selectivity against other dehydrogenases. AGI-6780 reverses the IDH2/R140Q-induced differentiation block in TF-1 cells, and induces blast differentiation in primary human IDH2/R140Q AML patient samples.
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