[CAS NO. 1202759-32-7] CNX-774
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PRODUCTS SPECIFICATIONS [1202759-32-7]
Store
Catalog
SLK-S7257
Brand
Selleck
CAS
1202759-32-7
DESCRIPTION [1202759-32-7]
Overview
| MDL | MFCD26405992 |
|---|---|
| Molecular Weight | 499.5 |
| Molecular Formula | C26H22FN7O3 |
| SMILES | O=C(NC)C1=NC=CC(OC2=CC=C(NC3=NC=C(F)C(NC4=CC=CC(NC(C=C)=O)=C4)=N3)C=C2)=C1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.0020 mL | 10.0100 mL | 20.0200 mL |
| 5 mM | 0.4004 mL | 2.0020 mL | 4.0040 mL |
| 10 mM | 0.2002 mL | 1.0010 mL | 2.0020 mL |
| 50 mM | 0.0400 mL | 0.2002 mL | 0.4004 mL |
Description
CNX-774 is an irreversible, orally active, and highly selective inhibitor with of <1 nM.
Features
Orally bioavailable BTK-selective inhibitor, binding covalently to target protein.
Targets
| BTK [1] |
| <1 nM |
In vitro
In cellular assays, CNX-774 demonstrates potent inhibitory activity towards BTK with IC50 of 1-10 nM by targeting Cys-481 residue within the ATP binding site of the enzyme.
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