[CAS NO. 1226895-15-3] FLLL32
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PRODUCTS SPECIFICATIONS [1226895-15-3]
Store
Catalog
SLK-S7259
Brand
Selleck
CAS
1226895-15-3
DESCRIPTION [1226895-15-3]
Overview
| MDL | MFCD27976793 |
|---|---|
| Molecular Weight | 464.55 |
| Molecular Formula | C28H32O6 |
| SMILES | O=C(C1(C(/C=C/C2=CC=C(OC)C(OC)=C2)=O)CCCCC1)/C=C/C3=CC=C(OC)C(OC)=C3 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1526 mL | 10.7631 mL | 21.5262 mL |
| 5 mM | 0.4305 mL | 2.1526 mL | 4.3052 mL |
| 10 mM | 0.2153 mL | 1.0763 mL | 2.1526 mL |
| 50 mM | 0.0431 mL | 0.2153 mL | 0.4305 mL |
Description
FLLL32 is a potent inhibitor with of <5 μM. FLLL32 inhibits the induction of STAT3 phosphorylation by and in breast cancer cells.
Targets
| JAK2 [1] |
| <5 μM |
In vitro
In MDA-MB-231 breast and PANC-1 pancreatic cancer cells, FLLL32 downregulates STAT3 phosphorylation and DNA-binding activity. In MDA-MB-231 cells, FLLL32 inhibit the formation of colonies and cell invasion. In human multiple myeloma, glioblastoma, liver cancer, and colorectal cancer cell lines, FLLL32 also leads to the inhibition of cell proliferation and the induction of caspase-3 and PARP cleavages.
In vivo
In MDA-MB-231 xenografted mice, FLLL32 (50 mg/kg, i.p.) significantly reduces tumor burdens. In mouse xenografts with OS-33 osteosarcoma cells, FLLL32 (50 mg/kg, i.p.) also inhibits tumor growth by targeting STAT3.
References
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