[CAS NO. 1229194-11-9] Edoxaban tosylate Monohydrate

Name: Edoxaban tosylate Monohydrate
Brand: Arctom Scientific
SKU: SLK-S7280

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PRODUCTS SPECIFICATIONS [1229194-11-9]

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Catalog

SLK-S7280

Brand

Selleck

CAS

1229194-11-9

DESCRIPTION [1229194-11-9]

Overview

MDL	MFCD28400751
Molecular Weight	738.27
Molecular Formula	C24H30ClN7O4S.C7H8O3S.H2O
SMILES	S(=O)(=O)(O)C1=CC=C(C)C=C1.N(C(=O)C1=NC2=C(S1)CN(C)CC2)[C@H]3[C@@H](NC(C(NC4=CC=C(Cl)C=N4)=O)=O)CC[C@H](C(N(C)C)=O)C3.O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.3545 mL	6.7726 mL	13.5452 mL
5 mM	0.2709 mL	1.3545 mL	2.7090 mL
10 mM	0.1355 mL	0.6773 mL	1.3545 mL
50 mM	0.0271 mL	0.1355 mL	0.2709 mL

Description

Edoxaban (DU-176b) is a selective inhibitor with of 0.561 nM, >10 000-fold selectivity over thrombin and FIXa, and is also an orally bioavailable anticoagulant drug.

Targets

Factor Xa ^[1]
(Cell-free assay)

0.561 nM(Ki)

In vitro

In human plasma, Edoxaban doubles prothrombin time and activates partial thromboplastin time at 0.256 and 0.508 μM, respectively.

In vivo

Oral administration of Edoxaban produces potent anti-Xa activity and high drug concentration in plasma in rats and monkeys. In vivo, Edoxaban dose-dependently inhibits thrombus formation in rat and rabbit thrombosis models.

References

[1] Furugohri T, et al. J Thromb Haemost. 2008, 6(9), 1542-1549.

Synonyms

Ethanediamide, N¹-(5-chloro-2-pyridinyl)-N²-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-, 4-methylbenzenesulfonate, hydrate (1:1:1)

N-(5-Chloropyridin-2-yl)-N′-((1S,2R,4S)-4-[(dimethyl amino)carbonyl]-2-[[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl)ethanediamide p-toluenesulfonate monohydrate

N-(5-Chloropyridin-2-yl)-N′-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]ethanediamide mono(p-toluenesulfonate) monohydrate

Edoxaban tosylate hydrate

Edoxaban tosylate monohydrate