[CAS NO. 1219168-18-9] Dorsomorphin (Compound C) 2HCl
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PRODUCTS SPECIFICATIONS [1219168-18-9]
Store
Catalog
SLK-S7306
Brand
Selleck
CAS
1219168-18-9
DESCRIPTION [1219168-18-9]
Overview
| MDL | MFCD11112197 |
|---|---|
| Molecular Weight | 472.41 |
| Molecular Formula | C24H25N5O.2HCl |
| SMILES | [H]Cl.[H]Cl.C12=C(C3=CC=NC=C3)C=NN1C=C(C4=CC=C(OCCN5CCCCC5)C=C4)C=N2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1168 mL | 10.5840 mL | 21.1681 mL |
| 5 mM | 0.4234 mL | 2.1168 mL | 4.2336 mL |
| 10 mM | 0.2117 mL | 1.0584 mL | 2.1168 mL |
| 50 mM | 0.0423 mL | 0.2117 mL | 0.4234 mL |
Description
Dorsomorphin 2HCl (BML-275, Compound C) is a potent, reversible, selective inhibitor with of 109 nM in cell-free assays, exhibiting no significant inhibition of several structurally related kinases including ZAPK, SYK, PKCθ, PKA, and JAK3. Also inhibits activity. Dorsomorphin induces in cancer cell line.
In vitro
Dorsomorphin inhibits ACC inactivation by either AICAR or metformin, and also attenuates AICAR and metformin’s effect to increase fatty acid oxidation or suppress lipogenic genes in hepatocytes. Inhibition of AMPK activity by Dorsomorphin almost completely inhibits autophagic proteolysis in HT-29 cells. In addition, Dorsomorphin selectively inhibits the BMP type I receptors ALK2, ALK3 and ALK6, and thus blocks BMP-mediated SMAD1/5/8 phosphorylation, target gene transcription and osteogenic differentiation.
References
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