[CAS NO. 894187-61-2] STF-118804
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PRODUCTS SPECIFICATIONS [894187-61-2]
Store
Catalog
SLK-S7316
Brand
Selleck
CAS
894187-61-2
DESCRIPTION [894187-61-2]
Overview
| MDL | MFCD14918065 |
|---|---|
| Molecular Weight | 461.53 |
| Molecular Formula | C25H23N3O4S |
| SMILES | O=C(NCC1=CC=CN=C1)C2=CC=C(C3=NC(CS(=O)(C4=CC=C(C)C=C4)=O)=C(C)O3)C=C2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1667 mL | 10.8335 mL | 21.6671 mL |
| 5 mM | 0.4333 mL | 2.1667 mL | 4.3334 mL |
| 10 mM | 0.2167 mL | 1.0834 mL | 2.1667 mL |
| 50 mM | 0.0433 mL | 0.2167 mL | 0.4333 mL |
Description
STF-118804 is a highly specific inhibitor.
Targets
| NAMPT [1] |
In vitro
STF-118804 reduces the viability of B-ALL cell lines containing MLL chromosomal translations, with IC50 values in the low nanomolar range. In addition, leukemic samples from five pediatric ALL patients are also sensitive to STF-118804 in the low nanomolar range. STF-118804 induces leukemia MV411 cell apoptosis without antecedent cell cycle arrest.
In vivo
STF-118804 (25 mg/kg twice daily, s.c.) improves survival in an orthotopic xenotransplant model of high-risk acute lymphoblastic leukemia, and effectively depletes leukemia-initiating cells.
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