[CAS NO. 1314890-29-3] TMP269
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PRODUCTS SPECIFICATIONS [1314890-29-3]
Store
Catalog
SLK-S7324
Brand
Selleck
CAS
1314890-29-3
DESCRIPTION [1314890-29-3]
Overview
| MDL | MFCD26522023 |
|---|---|
| Molecular Weight | 514.52 |
| Molecular Formula | C25H21F3N4O3S |
| SMILES | O=C(NCC1(C2=NC(C3=CC=CC=C3)=CS2)CCOCC1)C4=CC=CC(C5=NOC(C(F)(F)F)=N5)=C4 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.9436 mL | 9.7178 mL | 19.4356 mL |
| 5 mM | 0.3887 mL | 1.9436 mL | 3.8871 mL |
| 10 mM | 0.1944 mL | 0.9718 mL | 1.9436 mL |
| 50 mM | 0.0389 mL | 0.1944 mL | 0.3887 mL |
Description
TMP269 is a potent, selective class IIa inhibitor with of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively.
Targets
In vitro
TMP269 has no impact on the mitochondrial activity and/or the viability of human CD4+ T cells at 10 μM, and may be used as tools to identify the endogenous substrates of the class IIa HDAC enzymes. In IEC-18 intestinal epithelial cells, TMP269 prevents cell cycle progression, DNA synthesis, and proliferation induced in response to G protein-coupled receptor/PKD1 activation.
References
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