[CAS NO. 147591-46-6] ID-8
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PRODUCTS SPECIFICATIONS [147591-46-6]
Store
Catalog
SLK-S7327
Brand
Selleck
CAS
147591-46-6
DESCRIPTION [147591-46-6]
Overview
| MDL | MFCD00593367 |
|---|---|
| Molecular Weight | 298.29 |
| Molecular Formula | C16H14N2O4 |
| SMILES | OC1=CC2=C(C=C1)C([N+]([O-])=O)=C(C)N2C3=CC=C(OC)C=C3 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.3524 mL | 16.7622 mL | 33.5244 mL |
| 5 mM | 0.6705 mL | 3.3524 mL | 6.7049 mL |
| 10 mM | 0.3352 mL | 1.6762 mL | 3.3524 mL |
| 50 mM | 0.0670 mL | 0.3352 mL | 0.6705 mL |
Description
ID-8 is a inhibitor, and sustains embryonic stem cell self-renewal in long-term culture.
Targets
| DYRK [1] |
In vitro
ID-8 reversibly maintains the long-term culture of ESCs by sustaining Nanog gene expression through Sox2-Oct3/4 activation. ID-8 enhances Wnt-mediated hESC survival and proliferation via inhibition of DYRKs. The mechanism study indicates that ID-8 maintains the undifferentiated state in the presence of Wnt by modulating Wnt/β-catenin signaling and enhancing the CBP/β-catenin association in hESCs.
References
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